J Curve in Patients Randomly Assigned to Different Systolic Blood Pressure Targets
نویسندگان
چکیده
منابع مشابه
Blood Pressure J-Curve: Current Concepts
The blood pressure (BP) J-curve debate started in 1979, and we still cannot definitively answer all the questions. However, available studies of antihypertensive treatment provide strong evidence for J-shaped relationships between both diastolic and systolic BP and main outcomes in the general population of hypertensive patients, as well as in high-risk populations, including subjects with coro...
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We have enough evidences that uncontrolled hypertension increases cardiovascular morbidity and lowering elevated BPs can reduce such events1. The question that now arises is to what level should the BP be lowered to optimize treatment? Lower the better has been a dictum for most of the physicians over the last few decades2. But recently some data have emerged which focused on the dangers of low...
متن کاملJ-curve revisited: An analysis of blood pressure and cardiovascular events in the Treating to New Targets (TNT) Trial.
AIM In patients with coronary artery disease (CAD), a J-curve relationship has been reported between blood pressure (BP) and future cardiovascular events. However, this is controversial. The purpose of the study was to determine the relationship between on-treatment BP and cardiovascular outcomes in patients with CAD. METHODS AND RESULTS We evaluated 10 001 patients with CAD and a low-density...
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The blood pressure J-curve discussion has been ongoing for more than 30 years, yet there are still questions in need of definitive answers. On one hand, existing antihypertensive therapy studies provide strong evidence for J-curve-shaped relationships between both diastolic and systolic blood pressure and primary outcomes in the general hypertensive patient population, as well as in high-risk p...
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The Systolic Blood Pressure (SBP, mm Hg) Intervention Trial (SPRINT) showed that targeting SBP <120 mm Hg (intensive treatment, mean SBP: 121.5 mm Hg) versus <140 (standard treatment, mean SBP: 134.6 mm Hg) reduced cardiovascular events 25%. SPRINT has 2 implicit assumptions that could impact future US hypertension guidelines: (1) standard therapy controlled SBP similarly to that in adults with...
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ژورنال
عنوان ژورنال: Circulation
سال: 2017
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.117.030342